Dissecting the early steps of MLL induced leukaemogenic transformation using a mouse model of AML.

Additionally, this difference increased further after 72 h (14.2-fold decrease of ME-Transformed IC50 value compared to the negative controls), and was highly significant ( p value < 0.001 at 48 h and <0.0001 at 72 h).

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Of note, there was a trend towards higher expression of the transgene in MLL-ENL1 cells compared to MLL-ENL2 cells, although it did not reach statistical significance ( p value > 0.05), as shown in Fig. 4c .

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