Monocarboxylate transporter 1 blockade with AZD3965 inhibits lipid biosynthesis and increases tumour immune cell infiltration.

Br J Cancer · 2020 · PMC7078321 · PMID 31937921

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Interestingly, AZD3965 treatment showed a trend towards inhibition of other rate-limiting lipogenic enzymes (ACC and P-ACL) in MCT4− Raji cells, potentially suggesting an overall decline in lipid biosynthesis following MCT1 inhibition in this model.

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