Barely Significant
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Impact of EMA regulatory label changes on systemic diclofenac initiation, discontinuation, and switching to other pain medicines in Scotland, England, Denmark, and The Netherlands.

Pharmacoepidemiol Drug Saf · 2020 · PMC7079064 · PMID 31899936

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a negative trendno p-value reported
In Denmark, the regulatory action was associated with a significant immediate fall in diclofenac initiation in people with osteoarthritis and change to a negative trend in people with osteoarthritis and inflammatory arthropathies compared with baseline ( Table S2 ).

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