Also reflective of their reduced soma size, the membrane capacitance (C m ) of Raptor-KO neurons was significantly lower than that of Raptor-Con neurons (Con: 138 ± 8.2 pF, Rap-KO: 87 ± 7.4 pF, p<0.001); however, the effect of Rictor loss on reducing the C m did not reach statistical significance (Con: 173 ± 14 pF, Ric-KO: 135 ± 10 pF, p=0.065).
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Genetic inactivation of mTORC1 or mTORC2 in neurons reveals distinct functions in glutamatergic synaptic transmission.
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