Transcription factor p73 regulates Th1 differentiation.

In the spinal cord, however, after MOG 35–55 stimulation, although not statistically significant, there was a possible trend toward an increase in the IL-17A + and FoxP3 + CD4 + T cells infiltrating the spinal cord in Trp73 −/− mice, a nearly significant increase in the percentage of IFNγ-producing CD4 + cells, and increased CD25 expression (Fig. 6d ), consistent with p73 negatively regulating Il2ra expression (Figs. 3e and 5e ).

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