Heart failure disease management: a systematic review of effectiveness in heart failure with preserved ejection fraction.

Three studies failed to demonstrate significant improvement 18 , 25 , 28 ; one study 19 did not reach statistical significance but demonstrated a clinically meaningful improvement in quality of life as measured by KCCQ; and five studies reported a statistically significant improvement in the intervention arm. 17 , 20 , 27 , 29 , 35 3.5.5 The effect of disease management programmes on anxiety, depression, and sleep qualit

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