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Natural product-derived icaritin exerts anti-glioblastoma effects by positively modulating estrogen receptor β.

Exp Ther Med · 2020 · PMC7086240 · PMID 32256768

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The protein expression levels of total Akt in U87-MG and C6 cells treated with 50 μM of icaritin were decreased, although this did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.