Low-dose 17α-ethinyl estradiol (EE) exposure exacerbates lupus renal disease and modulates immune responses to TLR7/9 agonists in genetically autoimmune-prone mice.

Both TLR7 and TLR9 agonists were able to elicit responses for TNFα, IL12-p70, IFNγ, IL-2, and IL-17 in both control and EE diet group, although some changes did not reach statistical significance.

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