Central venous oxygen saturation showed a trend to increase with PEEP, and although not significant, this in combination with the trend of increasing oxygen consumption indicates that a decrease in CO was not the predominant mechanism for the observed shunt reduction from low to high levels of PEEP.
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Changes in shunt, ventilation/perfusion mismatch, and lung aeration with PEEP in patients with ARDS: a prospective single-arm interventional study.
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