Computers and viral diseases. Preliminary bioinformatics studies on the design of a synthetic vaccine and a preventative peptidomimetic antagonist against the SARS-CoV-2 (2019-nCoV, COVID-19) coronavirus.

Type II transmembrane serine proteases are likely targets for cleavage activation of 2019-nCoV based on studies of SARS-CoV, but they still require clarification as to the natural sequences typically cleaved, and as discussed in Section 4.7 , the relation between KRSFIEDLLFNKV from 2019-nCoV and a model substrate sequence for type II transmembrane serine proteases, AEAALRKLLEVA, is probably not significant.

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