Large-scale production and purification of VLP-based vaccines.

J Invertebr Pathol · 2011 · PMC7094596 · PMID 21784230

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a clear trendno p-value reported

A clear trend is observed from laboratory purification methods like sucrose or cesium chloride gradient ultracentrifugation procedures towards scalable processes like tangential flow filtration and chromatography ( Morenweiser, 2005 ).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.