Dietary intake of bioactive ingredients impacts liver and adipose tissue transcriptomes in a porcine model of prepubertal early obesity.

Moreover, we identified with Cluego highly significant reactome pathways such as extracellular matrix organization, degradation of the extracellular matrix and collagen formation; GO biological processes such as blood vessel development and angiogenesis, and KEGG pathways such as PI3K-Akt signaling pathway, enriched with genes upregulated in the T3 group.

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Serum concentrations of total cholesterol and both LDL- and HDL-cholesterol, as well as concentrations of triglycerides, were higher in piglets with a high calorie intake, either with or without bioactive supplementation (T2, T3 and T4), than in the control group (T1), although some of the comparisons did not reach statistical significance.

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