Dual HER2 Blockade versus a Single Agent in Trastuzumab-Containing Regimens for HER2-Positive Early Breast Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

J Oncol · 2020 · PMC7102417 · PMID 32256583

Europe PMC DOI

hedged sentences

0.4500

closest p · 9.0× alpha

0.4500

boldest claim

The sentences

did not reach statistical significancep =0.45not close (p > 0.1)

The difference in ORR did not reach statistical significance in either the pooled analysis (RR 1.03, 95% CI 0.96–1.10, p =0.45) or the subgroup analysis of the dual anti-HER2 regimen. 3.2.4.

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marginally significantno p-value reported

And it is statistically possible that the pooled analysis showed a marginally significant result after expanding the sample size by integrating several trials that are close to meaningful.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.