Barely Significant
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Loss of p16 and high Ki67 labeling index is associated with poor outcome in esophageal carcinoma.

Oncotarget · 2020 · PMC7105162 · PMID 32256975

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Other parameters, such as tumor stage and grade barely failed to reach statistical significance, which was probably first of all due to the low number of samples in some subgroups. p16 loss or downregulation but also its clear overexpression has been evaluated as negative prognosticators in several tumor types.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.