nominally significantp <0.05
A signal was considered to replicate if: i) it met our Bonferroni corrected gene-level significance threshold ( p <1.32x10 -7 ); ii) >2 variants were tested; iii) it was nominally significant ( p <0.05) in the unadjusted test for WGS (i.e. without adjusting for correlated traits).