Response rate of patients with baseline brain metastases from recently diagnosed non-small cell lung cancer receiving radiotherapy according to EGFR, ALK and KRAS mutation status.

Thorac Cancer · 2020 · PMC7113051 · PMID 32072746

Europe PMC DOI

hedged sentences

0.1000

closest p · 2.0× alpha

0.1000

boldest claim

The sentences

borderline significantP < 0.1so close (0.05 < p ≤ 0.1)

Statistically significant and borderline significant variables ( P < 0.1) were included for the adjustment in the multivariate Cox regression model and hazard ratios (HR) were calculated along with their corresponding 95% CIs as a measure of association.

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did not reach statistical significanceno p-value reported

However, to the best of our knowledge, this is the first prospective observation in terms of KRASm patients without systemic therapy, and our data suggests that this NSCLC genotype has a lower response rate to WBI (20.0%) compared to other common mutations and WT patients; however, this did not reach statistical significance in the multivariate analysis, probably due to a limited sample size.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.