Furthermore, vaccine alone elicited more IgG1 production than IgG2a, whereas Protollin adjuvantation induced a mixed IgG1 and IgG2a response with a clear trend towards a T H 1 response (IgG2a-dominant) ( Fig.2 B and D).
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Nasal delivery of Protollin-adjuvanted H5N1 vaccine induces enhanced systemic as well as mucosal immunity in mice.
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