Biomarker Exploration in Human Peripheral Blood Mononuclear Cells for Monitoring Sulforaphane Treatment Responses in Autism Spectrum Disorder.

cytoprotective or pro-inflammatory), differences from baseline were highly significant at the 95% confidence level by ANOVA (F 1,52 = 8.82, p < 0.005 for cytoprotective genes and F 1,46 = 9.25, p < 0.004 for pro-inflammatory genes) (Fig. 6c ).

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Perhaps due to the relatively small sample size, the increased expression of individual cytoprotective markers (NQO1, AKR1C1, HO-1, HSP70 and HSP27) and the decreased expression of most individual pro-inflammatory markers (IL-6, IL-1β and TNF-α), except that of COX-2, after 2 weeks of SF treatment did not reach statistical significance.

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