Structure, stability and function of RNA pseudoknots involved in stimulating ribosomal frameshifting.

The molecular origin of these perturbations are not known and may have to do with subtle differences in the energetics of the unfolded state, but are often quite significant and can even dictate whether or not the pseudoknotted conformation will be the major conformer at equilibrium at 37 °C Theimer et al 1998 , Theimer and Giedroc 1999 .

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