Development of an SPE-HPLC-MS method for simultaneous determination and pharmacokinetic study of bioactive constituents of Yu Ping Feng San in rat plasma after oral administration.

The pharmacokinetic parameters terminal half-life (HL λz ), maximum concentration in plasma ( C max ), and the area under the plasma concentration–time curve (AUC) from dosing time extrapolated to infinity (AUC 0- ∞ ) showed a trend of dose-dependence towards the detected constituents cycloastragenol, calycosin, GMV and cimifugin in YPFS , based on the doses administered orally (10, 20 and 40 g/kg; Fig. 4 , Table 5 ).

also in 53,322 other papers