Barely Significant
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Evaluation of the 'ring sign' and the 'core sign' as a magnetic resonance imaging marker of disease activity and progression in clinically isolated syndrome and early multiple sclerosis.

Mult Scler J Exp Transl Clin · 2020 · PMC7132556 · PMID 32284875

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showed a trendno p-value reported
12 Our data, which includes a follow-up of up to 4.6 years did not show an enlargement of ‘ring sign’ lesions over time, but in contrast to ‘core sign’ lesions, ‘ring sign’ lesions did not shrink and showed a trend towards more enlargement compared to other lesions.

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