Pregnenolone Inhibits Osteoclast Differentiation and Protects Against Lipopolysaccharide-Induced Inflammatory Bone Destruction and Ovariectomy-Induced Bone Loss.

Front Pharmacol · 2020 · PMC7135856 · PMID 32292342

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showed a trendno p-value reported

The gene ATP6V0d2 which encodes the d2 subunit of the V-ATPase proton pump which has been implicated to be important for both precursor cell fusion and mature osteoclast bone resorption ( Lee et al., 2006 ; Kim et al., 2008 ; Wu et al., 2009 ; Crasto et al., 2013 ; Takagi et al., 2017 ) showed a trend of decrease following Preg treatment.

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