Targeting the pregnane X receptor using microbial metabolite mimicry.

EMBO Mol Med · 2020 · PMC7136958 · PMID 32153125

Europe PMC DOI

hedged sentences

0.0560

closest p · 1.1× alpha

0.0700

boldest claim

The sentences

borderline significanceP = 0.056so close (0.05 < p ≤ 0.1)

Interestingly, CYP3A4, a target gene that is only modestly (as opposed to MDR1) elevated in intestinal cell lines exposed to FKK5 (Fig 1 C), was also only slightly increased in the HIO experiments ( Appendix Fig S1A : borderline significance for CYP3A4, P = 0.056).

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did not reach statistical significanceP = 0.07so close (0.05 < p ≤ 0.1)

Similarly, FKK6 (10 μM) reduced IL‐8 mRNA levels in organoids; however, this decrease did not reach statistical significance ( P = 0.07; Fig 4 B).

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