Sarilumab and adalimumab differential effects on bone remodelling and cardiovascular risk biomarkers, and predictions of treatment outcomes.

Increases in P1NP, though numerically increased by sarilumab treatment relative to adalimumab, did not reach statistical significance in the steroid subgroups (median percentage change from baseline in P1NP [interquartile range]: with baseline steroid use, 24.6% [− 0.6 to 50.3%] with sarilumab and 7.5% [− 9.9 to 40.3%] with adalimumab [nominal p = 0.0757]; without baseline steroid use, 18.0% [− 3.5 to 47.2%] with sarilumab and 1.8% [− 13.9 to 31.9%] with adalimumab [nominal p = 0.1625]).

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