Metabolism-associated molecular classification of hepatocellular carcinoma.

Although no significant difference in driver genes' amplification was observed between pairs of subclasses, C2 still showed a trend toward higher amplification rate (e.g., FGF19: 9.09%) than C1 (7.07%, P = 0.59) and C3 (4.31%, P = 0.21; detailed statistical analyses are shown in Table S10 ). 3.7 Ninety‐gene classifier and performance validation Differential analysis yielded 509 significant genes for the C1 subclass, 2042 for the C2 subclass, and 279 for the C3 subclass.

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