The Determination of Immunomodulation and Its Impact on Survival of Rectal Cancer Patients Depends on the Area Comprising a Tissue Microarray.

Cancers (Basel) · 2020 · PMC7139832 · PMID 32121328

Europe PMC DOI

hedged sentence

0.0870

closest p · 1.7× alpha

0.0870

boldest claim

The sentences

showed a trendp = 0.087so close (0.05 < p ≤ 0.1)

Here, CD3 density and PD-1 expression in both tumor areas (CT, IM) showed a significant impact on both DFS and OS (CD3: CT, p = 0.018/IM, p = 0.002 and PD-1: CT, p = 0.037/IM, p = 0.016, respectively), whilst PD-L1 expression showed a trend towards improved survival (PD-L1: CT, p = 0.087/IM, p = 0.078); with regard to CD8 density, only expression in the IM was associated with improved survival.

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