approached significancep -value < 0.1
At 22 of the 41 CpGs, the associations of DNA-M changes with changes in FEV 1 /FVC were consistent with the findings in the IOW cohort, with one CpG showing statistical significance at 0.05 level (cg14552568) and two CpGs approached significance (cg01082111 and cg10027934, p -value < 0.1).