Proteoglycan 4 is Increased in Human Calcified Aortic Valves and Enhances Valvular Interstitial Cell Calcification.

In addition, PRG4 expression in healthy regions of the aortic valve was significantly and positively associated with BMP2, DMP1, IBSP, and IL6, whereas the association with RUNX2 did not reach statistical significance ( Figure 1 B).

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