Shared Molecular Genetic Mechanisms Underlie Endometriosis and Migraine Comorbidity.

Genes (Basel) · 2020 · PMC7140889 · PMID 32121467

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.1000

boldest claim

The sentences

highly significantP = 2.30 × 10 −25actually significant

Linkage disequilibrium score regression analysis found a positive and highly significant genetic correlation ( r G = 0.38, P = 2.30 × 10 −25 ) between endometriosis and migraine.

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marginally significantP = 0.049actually significant

Nevertheless, we found evidence for marginally significant heterogeneity among the IVs (Cochran’s Q statistics for IVW = 18.39, degree of freedom [df] = 10, P = 0.049, and Q’ statistics for MR Egger = 16.99, df = 9, P = 0.049).

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nominally significantP < 0.1so close (0.05 < p ≤ 0.1)

We extracted nominally significant genes (at P < 0.1, P < 0.05, and P < 0.01) from Vegas2 outputs for each of the two traits and assessed those for overlapping genes between endometriosis and migraine.

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borderline significantno p-value reported

However, the difference between Q and its df (18.39 – 10 = 8.39) for IVW and (Q’, 16.99 – 9 = 7.99) for MR Egger are small, indicating (alongside the borderline significant p -value) that the heterogeneity was not substantial.

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