A presumed case of Darbepoetin-induced myocardial infarction in the patient with MDS-RARS.

6 Not surprisingly, in light of the pre‐existing diagnosis of RARS, a missense somatic mutation of SF3B1 was identified in our patient, which is among the 15 most commonly mutated genes seen in myeloid disorders and clonal hematopoiesis of indeterminate significance and is particularly prevalent (>80%) in patients MDS with ringed sideroblasts. 7 Our patient presented with an acute coronary syndrome on the background of no cardiovascular risk factors except a history of low‐grade MDS requiring regular darbepoetin infusions.

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