Looping of upstream cis-regulatory elements is required for CFTR expression in human airway epithelial cells.

Nucleic Acids Res · 2020 · PMC7144911 · PMID 32095812

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did not reach statistical significanceno p-value reported

However, in intestinal cells a slight increase in CFTR expression upon deletion of the −20.9 kb site did not reach statistical significance ( 10 ), but siRNA-mediated depletion of CTCF caused a significant increase in expression of the gene ( 26 ).

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