Arachidonic Acid in Human Milk.

For this discussion, it was most important that the authors noted: “ The most significant associations and the highest proportion of genetically explained variability (28%) were found for arachidonic acid (C20:4n-6) .” The minor alleles had a fairly significant frequency; for example, the rs174583polymorphism in the FADS2 gene had a minor allele (2/2) frequency of 13% and several others were 11–16%.

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The importance of this finding is that while the DHA-supplemented formula resulted in a 4-point increase in the mean score, it did not reach statistical significance, demonstrating the clear combined benefit of the presence of both ARA and DHA in the infant’s diet during early development.

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