Inflammation (IL-1β) Modifies the Effect of Vitamin D and Omega-3 Long Chain Polyunsaturated Fatty Acids on Core Symptoms of Autism Spectrum Disorder-An Exploratory Pilot Study^‡.

In a 12-month, double-blind, randomised, placebo-controlled trial (VIDOMA trial), we previously found evidence for a greater improvement with omega-3 LCPUFA with or without vitamin D in social interaction in children with ASD compared with placebo but the difference did not reach statistical significance ( P < 0.05) for most comparisons.

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A two-sided P < 0.05 was considered statistically significant, and a P < 0.10 (borderline significant) suggestive of a trend for treatment effect.

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