Sperm Ribosomal DNA Promoter Methylation Levels Are Correlated With Paternal Aging and May Relate With <i>in vitro</i> Fertilization Outcomes.

Front Genet · 2020 · PMC7147477 · PMID 32318099

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0.0707

closest p · 1.4× alpha

0.0707

boldest claim

The sentences

nearly significantP = 0.0707so close (0.05 < p ≤ 0.1)

In contrast, the correlation between sperm rDNA promoter methylation levels and fertilization (2 pronuclei) rate was nearly significant ( P = 0.0707), especially the methylation levels of some individual CpG units (CpG_10, P = 0.0176; CpG_11, P = 0.0438; CpG_14, P = 0.0232) and rDNA promoter methylation levels measured using primerS2 ( P = 0.0513).

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