An initial small-scale double-blind trial with early RRMS patients showed a trend to better clinical outcomes, and a reduction in MBP-reactive T cells in myelin-treated patients, without any adverse effects ( Weiner et al., 1993a ; Hohol et al., 1996 ).
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However, other studies testing the prognostic value of anti-MOG and anti-MBP antibodies revealed controversial results ranging from highly significant to totally insignificant ( Berger et al., 2003 ; Tomassini et al., 2007 ; Kuhle et al., 2007a , Kuhle et al., 2007b ; Pelayo et al., 2007 ).
In PPMS, a single study reported significantly less patients with EDSS progression in the IVIG-treated group than in the placebo group, with a nonsignificant trend to a delay in time to disease progression ( Pohlau et al., 2007 ).