Approach to the Patient with HIV and Coinfecting Tropical Infectious Diseases

45 A Cochrane Review 49 analyzed the only three randomized, controlled trials published to date on the effects of anthelminthic therapy on HIV disease progression in antiretroviral naïve patients: (1) a randomized trial of praziquantel for schistosomiasis, which found a significant benefit of treatment on plasma HIV-1 RNA load (a lack of an increase with treatment, compared with an increase in viral load in the absence of treatment), with a nonsignificant trend towards a beneficial effect on CD4 + counts in HIV-infected individuals; 50 (2) a randomized, double-blind, placebo-controlled, cross-over trial of diethylcarbamazine for bancroftian filariasis, which reported a decrease in plasma HIV-1 RNA load (and a nonsignificant trend towards a beneficial effe

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Although this did not reach statistical significance, it is reminiscent of the experience with the high-titered Edmonston–Zagreb (EZ) vaccine.

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