Involvement of VCP/UFD1/Nucleolin in the viral entry of Enterovirus A species.

The data confirmed that siRNA of VCP significantly reduced the infection by EVA71, CVA16, CVA6 and CVA10, while siRNA of UFD1 reduced virus titers of EVA71 and CVA16, although the inhibitory effects on CVA6 and CVA10 did not reach statistical significance in current experimental settings ( Fig. 4 e). 3.5 UFD1 targets viral entry step but not replication during viral life cycle To further study how VCP and UFD1 interact with the enterovirus life cycle, we performed the time of addition assay testing the VCP inhibitor (NMS-873).

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