COVID-19 Coronavirus spike protein analysis for synthetic vaccines, a peptidomimetic antagonist, and therapeutic drugs, and analysis of a proposed achilles' heel conserved region to minimize probability of escape mutations and drug resistance.

Within the coronaviruses, there is some degree of conservation that suggests that NCYWPLNDYGF is a segment for the virus to conserve, and a hint that FNCTWPGF is the key part, but there are soon very clearly significant variations across coronaviruses of different hosts as we depart from the Wuhan seafood market isolate compared with the RSFIEDLLFNKV motif in the S2’ cleavage regions [ 3 ].

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