In the end, there is a clear trend in downstream processing from classical laboratorial purification methods like sucrose or cesium chloride gradient centrifugations toward more sophisticated techniques like tangential flow filtration, gel permeation chromatography, liquid chromatography, ion exchange chromatography, affinity chromatography, and size-exclusion chromatography, including the use of newer, disposable membrane technology [245] , [254] , [255] . 1.47.6.4.
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Viruses and Virus-Like Particles in Biotechnology: Fundamentals and Applications☆
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