Cytotoxic Property of <i>Grias neuberthii</i> Extract on Human Colon Cancer Cells: A Crucial Role of Autophagy.

[ 22 ] As observed in Figures 2(a) and 2(b) , no overexpression of Bax protein was detected in the RKO cell line, despite the overexpression of p53 in a dose-dependent manner; furthermore, an increase of Bcl-2 expression was detected in the Western blot assay ( Figure 2(b) ), although this did not reach statistical significance relative to the control ( Figure 2(a) ).

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