Genetic Risk Underlying Psychiatric and Cognitive Symptoms in Huntington's Disease.

Of the primary hypotheses, the following nominally significant associations were also observed: MDD PRS with apathy, ADHD PRS with violent/aggressive behavior, PD PRS with cognitive impairment, and (interestingly, given the relatively small training GWAS) OCD PRS with perseverative/obsessive behavior.

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The highly significant association between schizophrenia PRS and psychosis observed in our sample shows the benefits of a large sample size of patients with HD, along with a larger set of SNPs systematically selected for association with schizophrenia in a powerful schizophrenia GWAS.

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