LRRK2 maintains mitochondrial homeostasis and regulates innate immune responses to <i>Mycobacterium tuberculosis</i>.

Transfection of immunostimulatory dsDNA (ISD), which is recognized by cGAS and stimulates the STING/TBK1/IRF3 axis, induced blunted Ifnb expression in Lrrk2 KO BMDMs ( Figure 2B ), Lrrk2 KO peritoneal macrophages (PEM) (significant differences in Ifnb expression were measured between Lrrk2 KO and HET at baseline but induction differences failed to reach statistical significance via 2-way ANOVA Tukey post-hoc testing) ( Figure 2C ), Lrrk2 KO RAW 264.7 macrophages ( Figure 2D ), Lrrk2 KO mouse embryonic fibroblasts (MEFs) ( Figure 2E ), and Lrrk2 KD RAW 264.7 macrophages ( Figure 2F ).

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