Specifically, survival analysis revealed that higher mRNA expression of TEAD2 was significantly associated with a less favorable overall survival rate (P=0.0067) and there was a trend towards significance between higher mRNA expression of VGLL4 and poor overall survival rate (P=0.051).
Poor prognosis of patients with HCC with high expression of TEAD2 and VGLL4 Based on the log-rank test and TCGA database, abundant mRNA expression of TEAD2 [hazard ratio (HR), 1.61; 95% confidence interval (CI), 1.14–2.27; P=0.0067] was significantly associated with a poor OS rate in patients with HCC, and there was a tendency towards significance between TEAD4 (HR, 1.35; 95% CI, 0.95–1.91; P=0.085) and VGLL4 mRNA expression (HR, 1.42; 95% CI, 1–2.02; P=0.051), and a poor prognosis ( Fig. 2 ).