Small Molecule Inhibitor Adjuvant Surfactant Therapy Attenuates Ventilator- and Hyperoxia-Induced Lung Injury in Preterm Rabbits.

In the Ang2 group, treatment with a combination of Ang2 siRNA + CS showed a trend toward decreased lung compliance ( p = 0.07) ( Figure 4B ) while in the CHOP group, treatment with CHOP siRNA + CS resulted in increased lung compliance than treatment with CHOP siRNA alone ( p = 0.05) ( Figure 4A ). miR34a Inh showed the best compliance with no significant difference in all the three groups (CS with ventilation, miR34a Inh with ventilation and miR34a Inh + CS with ventilation) studied ( Figure 4C ).

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