Transgenic conversion of ω-6 to ω-3 polyunsaturated fatty acids via fat-1 reduces the severity of post-traumatic osteoarthritis.

Although a number of serum and synovial fluid cytokines analyzed did not reach statistical significance by diet or strain, we did observe that lean female fat-1 mice exhibited decreases in serum pro-inflammatory cytokines, including IFN-γ, TNF-α, and MCP-1, compared to lean female WT mice, providing a potential mechanism for the reduction in joint synovitis.

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