A comparison of methods accounting for batch effects in differential expression analysis of UMI count based single cell RNA sequencing.

Comput Struct Biotechnol J · 2020 · PMC7163294 · PMID 32322368

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failed to reach statistical significanceno p-value reported

Many potentially true DE genes revealed in scRNA-seq-based analysis failed to reach statistical significance in the bulk RNA-seq data analysis, analogous to the power loss of the aggregation-based method (pseudo_bulk) in the simulation results.

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