Safety, tolerability, pharmacokinetics and pharmacodynamics of parenterally administered dutogliptin: A prospective dose-escalating trial.

Br J Clin Pharmacol · 2020 · PMC7163368 · PMID 31912513

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

a nonsignificant trendP = .06so close (0.05 < p ≤ 0.1)

When pooling in respect to single or multiple‐dose administration, there was a nonsignificant trend towards more subjects in the multiple‐dose groups with at least 1 related systemic AE ( P = .06).

also in 5,406 other papers

did not reach statistical significanceno p-value reported

Results from AUC 0‐24h suggest that a steady state exposure was reached in this dose range, with no relevant accumulation upon repeated daily dosing, because mean accumulation ratios did not reach statistical significance.

also in 111,027 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.