Early antituberculosis drug exposure in hospitalized patients with human immunodeficiency virus-associated tuberculosis.

Rifampicin C max and conjugated bilirubin showed a positive trend, r = 0.26, P = .055 (Figure S1).

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Patients with an elevated lactate at presentation (>2.2 mmol L –1 ) had significantly higher rifampicin C max (median = 9.0 vs 6.5 μg mL –1 ; P = .002) and AUC 0–8 (median = 47.3 vs 36.7 mg h L –1 ; P = .006; Table 4 ) with a nonsignificant trend towards higher isoniazid and pyrazinamide C max and AUC 0–8 (Table 4 ).

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The median pyrazinamide C max in hospitalized patients was higher than outpatients (50.1 vs 46.8 μg mL –1 , P = .081) but this did not reach statistical significance (Table 2 and Figure 2 ).

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