First, at the overall level of fiber bundles, FA decreased in only 6 of 16 patients with WMH compared with normal subjects; yet the difference between the WMH‐NC and WMH‐MCI subgroups did not reach statistical significance.
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Microstructural disruption of the right inferior fronto-occipital and inferior longitudinal fasciculus contributes to WMH-related cognitive impairment.
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