Inhibition of myostatin prevents microgravity-induced loss of skeletal muscle mass and strength.

Myostatin inhibition had no significant effect on BMD from DEXA either on the ground or in flight; however, time following launch was highly significant (p < 0.0001) and time was interactive with spaceflight (p < 0.0001) but not myostatin inhibition treatment.

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Pitx2, a gene shown to be increased by microgravity in the gastrocnemius [ 36 ], showed a trend for an increase in flight IgG animals compared to ground controls and a significant increase (+1.54 fold) in flight animals in the quadriceps.

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